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Broad modifications of various positions of the minimal natural epitope recognized by the myelin-associated glycoprotein (MAG), a blocker of regeneration of neurite injuries, produced sialosides with nanomolar affinities.
These broad modifications are prevalent in the human genome [ 16].
Do we observe differences in broad modifications among BTSC types and neural stem cells?
Here, we examine variation in broad modifications among our five cell types.
We find substantial differences among cell types in broad modifications and bivalent promoters.
The mechanisms that create broad modifications are believed to be significantly different from those that create focal modifications [ 22].
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The Justice Department praised the decision to block the law for 2012 and welcomed "the court's agreement that South Carolina's law required broad modification in order to respond to the serious concerns raised by the attorney general that the law as written would exclude minority voters".
This broad modification was restricted to H3K9me3 and was not present with H3K27me3 in this region.
We operationally defined a broad modification as >50 kb in length.
We verified that a change in a broad modification affected gene expression of CACNG7.
We operationally define a peak as a broad modification if it is >50 kb in extent.
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