Sentence examples for broad modification to from inspiring English sources

We use the term "broad modification" to denote long regions of chromosomal space in which there is a given epigenetic modification present continuously (>50 kb), as opposed to focal regions of modification ("peaks") in a promoter or other region.

In this context, it is important to understand that for a vehicle to qualify as fully autonomous, it should be able to navigate itself in real traffic within roads which have not been specifically adapted for its use, but this does not mean that there will not be broader modifications to road infrastructure to accommodate the AVs.

The Justice Department praised the decision to block the law for 2012 and welcomed "the court's agreement that South Carolina's law required broad modification in order to respond to the serious concerns raised by the attorney general that the law as written would exclude minority voters".

Secondly, the genome undergoes broad epigenetic modification to a more PSC-like state, including demethylation of promoters for pluripotency-associated transcription factors such as Oct4 and Nanog and reactivation of the inactive X chromosome [ 60, 61].

This broad modification was restricted to H3K9me3 and was not present with H3K27me3 in this region.

(4) We detected significant and clear changes in broad modification areas for H3K27me3 and, to a lesser extent, for H3K9me3, implying that the processes creating or maintaining these broad modifications differed in activity among cell types; in one case we verified that this change in a broad modification affected gene expression.

Whether the experimentally observed broad modification of these regions is due to DNA looping and nucleosome wrapping or the proposed spreading mechanism needs to be further investigated.

Only regions that clearly displayed extended broad peaks that differed among cell types were considered to show a broad modification difference.

The mechanisms that create broad modifications are believed to be significantly different from those that create focal modifications [ 22].

We operationally defined a broad modification as >50 kb in length.

We verified that a change in a broad modification affected gene expression of CACNG7.