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These consequences amongst others, that result from SCD has a broad manifestation that affects various organ systems in the body [ 6], of which chronic kidney disease (CKD) is a part.
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Yet fully developed integrated care in its broadest manifestation requires person-centeredness.
Anterior segment mesenchymal dysgenesis (ASMD; OMIM 107250) is a broad congenital manifestation of failures affecting the development of the cornea and lens of the eye.
A broader visual manifestation is hip-hop's profound influence on the way people dress in general and on fashion in particular, from the sports arena to the runway.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations.
It is analogous, although broader in manifestation, to loss of imprinting, a phenomenon widely associated with malignancy.
However, a comprehensive collection of terms that is relevant for a complex human disorder with broad clinical manifestations, such as ASD, is a major challenge.
This may provide an explanation as to the controversial issue that the neuronal loss involving DRPL systems alone cannot account for the broad clinical manifestations of DRPLA.
Although optic atrophy remains the defining feature of DOA, recent reports published in Brain have highlighted the much broader phenotypic manifestations that can result from pathogenic OPA1 mutations (Amati-Bonneau et al., 2008; Hudson et al., 2008).
Autism, perhaps more than many other diagnoses, presents a broad range of manifestations, and one treatment (or nontreatment) does not fit all.
APS may affect any organ of the body, leading to a broad spectrum of manifestations [ 3].
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