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Accordingly, the broad involvement of the spectrin cytoskeleton with enteric microbial pathogens reveals a new potential target for therapeutic treatments of these infections.
Because of the broad involvement of the ubiquitin proteasome proteolysis in the regulation of protein turnover, this pathway may have a vital role in cancer development and progression (Yang, 2007).
There has been very broad involvement of the scientific community in the IARC Monograph Programme through participation in the Working Groups and service on the IARC Governing and Scientific Councils and ad hoc Advisory Board for the Monograph Programme.
In the case of T cells, the focus of this review, the T-cell receptor (TCR) repertoire has been found to affect a wide range of disease, including malignancy, autoimmune disorders and infectious diseases, and, given the broad involvement of the immune system in almost all of human health and disease, this reach should be expected to expand greatly.
Recent studies showed that TCR repertoire has been found to affect a wide range of diseases, including malignancy, autoimmune disorders and infectious diseases, and, given the broad involvement of the immune system in almost all of human health and disease, this reach should be expected to expand greatly [ 9].
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The up-regulation of MEFV gene expression in the CD and UC patients, as well as in the mouse models, can be explained by the broad involvement of pyrin, the MEFV encoded protein, in the regulation of the inflammasome molecular platform and the inflammatory process [12] [18].
Our findings suggest multiple cerebellar cortical plasticity mechanisms underlying simple spike suppression, and they implicate the broader involvement of the olivocerebellar module within the interstimulus interval.
A lack of medical knowledge was also mentioned as an important obstacle against a broader involvement of the practice nurse in this area.
Facing such challenges, some of the current efforts emphasize broader involvement of the research community in curation efforts (52), while others attempt to supplement or even replace manual curation with automated literature mining (53, 54).
Avakov made particular mention of the broad involvement of several arms of the security forces including special forces, National Guard and Army.
The results also demonstrate the implication of the brainstem in mediating these responses in humans and speak for a broad involvement of light in the regulation of brain function.
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