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Recently, the Sanger and Broad institutes performed two separate large studies (CGP and CCLE, respectively) where they linked genomic profiles of various cancer cell lines to pharmacological responses.
For many aspects of the omics analysis framework, tranSMART leverages Bioconductor [ 35] and GenePattern [ 36] (a system provided by the Broad Institutes), while G-DOC and iCOD use mainly tools developed in-house.
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The consortium is a collaborative framework that includes Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, The Rockefeller University, The Broad Institute of MIT and Harvard and Cold Spring Harbor Laboratory.
The co-Principal Investigators are Dr. John Maciejowski, Ph.D., Memorial Sloan Kettering Cancer Center, and Dr. Eliezer M. Van Allen, M.D., The Broad Institute of MIT and Harvard.
Researchers hope to capture some of that diversity with the recently announced Slim Initiative for Genomic Health, a $65 million partnership between the Broad Institute, a genomics research institute in Cambridge, MA, and the Carlos Slim Health Institute, a nonprofit based in Mexico City.
The Broad Institute was to become a joint effort between Harvard and M.I.T., headed by Dr. Lander, that would encourage scientists to collaborate to solve big problems in biology, genetics and genomics.
The Broad Institute primary research labs are at 415 Main Street (across the street from MIT's Biology Department and adjacent to the Whitehead Institute), at 320 Charles Street, and at 75 Ames Street.
With locations and ATMs in Cambridge and Lexington, along with mobile and, online banking services, MITFCU serves the greater MIT-Kendall Square communities which includes employees of Novartis (Cambridge), Lincoln Laboratory, Draper, Whitehead Institute, The Broad Institute, Phillips, and Forsyth.
GFP-hLC3B and shRNA-encoding lentiviral particles,were generated and transduced according to standard protocols given by the RNAi Consortium (The Broad Institute, MA USA) with minor modifications.
The gene set collections C1, C2, C3 of the MSigDB were downloaded from the Broad institute (http://www.broad.mit.edu/gsea/msigdb/) and loaded into R statistical environment.
Thus, we examined the molecular similarity between reclassified MFH samples and their predicted corresponding STS subtypes from different datasets using the Subclass Mapping (SubMap) methodology as previously described [14] (Gene Pattern Software, Version 3.0, Broad Institute, details in Data S1).
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