Sentence examples for broad initiation from inspiring English sources

Some broad core promoters exhibit properties of both narrow and broad initiation patterns where they exhibit propensity for one TSS.

Although a few DSPs have TATA boxes in both orientations[ 14], most lack TATA boxes and initiator elements in either direction and stimulate transcriptional initiation at multiple sites over broad initiation windows as a strong association between DPGs and CpG island is described in human genome [ 8, 10].

The events that occurred in October in Washington, D.C., suggest the need to ensure that future bioterrorism events involving B. anthracis contamination of envelopes incorporate new understanding of the aerosolization potential in the PDC environment, the need for extensive traceback of contaminated envelopes, and broad initiation of prophylaxis to all persons potentially exposed to spores.

Unmethylated CpG islands are often associated with broad transcription initiation (Core et al., 2008), likely because CpG islands deter nucleosome binding (Ramirez-Carrozzi et al., 2009; Fenouil et al., 2012).

Broader TSS initiation patterns may in theory be a consequence of non-specificity in the basal transcription machinery, and biological effects of such alterations on transcription are yet to be elucidated [ 8].

In contrast to the characterized, broad patterns of initiation at CpG-island promoters [ 1], bidirectional promoters have very distinct sites of initiation.

73, 74 Two-stage models with clonal expansion are based on the broad paradigm of initiation, promotion, transformation, and progression in carcinogenesis, which has been applied to numerous studies of chemically induced and radiation-induced tumors in experimental animals.

But as soon as she had imagined Prague she knew that it was what she wanted for him: something more than the slick game of opportunity and advancement, a broader and deeper initiation into old sophisticated Europe, into a grownup life with complications.

The large number of workers helped reduce selection bias and improve the heterogeneity of the snowball sample, as there was a broad range of snowball initiation points with limited links in each of the chains associated with the initiation point [ 33, 38, 39].

The histogram showed a broad distribution of the initiation times from 1.9 ms to 18.2 ms (mean 6.2±0.3 ms, n = 142).

Immune cells have a broad impact on tumour initiation, growth and progression, and many of these effects are mediated by proinflammatory cytokines.