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The observed broad expression patterns of some markers resemble the maturation spectrum seen for normal pre-B cells.
In addition, broad expression patterns of DNA methyl-transferases (Dnmts) in honey bees that include embryos and the adult nervous system [ 19], suggest that epigenetic controls of genome activities also play important roles in early development and in brain plasticity.
Since histone-modifying enzymes are promising drug targets modulating broad expression patterns of cancer-associated genes, the functional characterization of these important key players and their role in specific cancers is urgently needed.
For example, the broad expression patterns of UBQLN1, UBQLN2 and UBQLN4 suggest that it is likely that other tissues or organs, besides the brain, may be affected by mutations in those genes.
The fairly broad expression patterns of the reference markers, such as the transcriptional factor evenskipped which is expressed as seven stripes around an embryo, and the non-trivial variation of the number of nuclei (in the ±10% range), make it difficult to achieve the single nucleus accuracy for the registered point clouds.
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The very broad expression pattern of the murine DSCR1 genes is similar to that of the human genes.
The broad expression pattern of the SUB gSUB EGFP reporter was perhaps not to be expected in the light of those results.
Due to the broad expression pattern of RIα, this approach to selectively inhibit PKA activity using the Cre/loxP system should prove useful for the study of PKA signaling in many different cellular and physiological responses in vivo.
The results showed a broad expression pattern of the mRNA.
The broad expression pattern of HAM genes suggests that they may be involved in several aspects of development, rather than gametophyte-specific genes.
This is in contrast to the broad expression pattern of the major photopigment exo-rhodopsin, which is distributed throughout the zebrafish pineal organ [ 24].
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