Although minor histocompatibility antigens (MiHA) represent promising targets, broad expression of these antigens has been associated with poor responses and T cell dysfunction that may not be prevented by targeting MiHA with limited expression.
A guided hands-on practical exercise in sedimentology and stratigraphy, palaeoenvironmental analysis and Palaeolithic archaeology was supported by the development of a 'Quaternary Timeline' chart, which introduces the concepts of changing climates and environments and characterises the broad expression of these changes in the terrestrial and fossil records.
We also demonstrate broad expression of these regulators in various extragonadal adult tissues.
Expression studies fail to find broad expression of these other TAAR family members in the brain but rather observe localization predominantly in the olfactory apparatus [ 1, 14].
Broad expression of this type was also observed frequently in the stigma, implying functional involvement in pollen pistil interaction.
Platypus genes α/α, α2 and β, whose orthologues are usually expressed in the bone marrow of an adult human, were expressed in almost all platypus tissues tested, suggesting a broader expression of these genes in the monotreme lineage.
Recent studies indicating a broader expression of these genes in many organisms, in cells with stem cell properties, have argued their role maybe more multipotent than purely germline (Gustafson and Wessel, 2010).
Remarkably, despite the broad expression of mTERT, these animals did not display a higher cancer incidence compared to control mice.
In contrast to the broad expression of kcnh4b (data not shown), kcnh4a is expressed specifically in the forebrain and hypothalamus in larvae.
Given the broad expression of Megf8 in a wide range of tissues during development, we next asked whether these defects, and in particular the TG defect, are due to a cell autonomous function of Megf8 in sensory neurons.
Apart from the different effects of sparse and broad expression of TrkB.T1 on excitatory synapses, we found that inhibitory synapses onto TrkB.T1 expressing cells are also affected differentially in these 2 mouse lines, but in the opposite way.
