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It is also evident that ifna1 has fairly broad expression in the tissues examined here.
CD19 is an attractive target for B-cell malignancies due to its broad expression in the B-cell lineage.
Interestingly, the initially broad expression in the central nervous system became restricted at E11.5 to the now paired teloceles leaving mesencephalon and rhombencephalon almost void of expression.
Despite broad expression in the nervous system and relatively dramatic defects in synapse formation and axon development, very mild abnormalities in behavior have been found in animals lacking PHR protein function.
For 53% (44/83) of this subset of genes with brain staining, all seven of the sub-structures were positive, indicating broad expression in the central nervous system for these genes (Fig. 3A).
Our EGL-3::GFP plasmid reporter, as previously reported (Kass et al., 2001), exhibited broad expression in the nervous system (Fig. 6A, NR and VNC) and the intestine (Fig. 6A, IN).
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Two other groups published similar findings using Cre transgenic mouse lines with broader expression in the retina [ 10] and throughout the CNS [ 11].
TLR7 and TLR9, the receptors for the viral PAMPs R-848 and CpG ODN, respectively, have a broader expression in the immune system than TLR3 and couple to the MyD88 rather than TRIF adapter protein.
(B ) Immunohistochemistry for pERK reveals broad expression in both the E13.5 anterior palatal mesenchyme (red arrowhead) and epithelium (black arrowhead).
The FruMB isoform, like FruMC, shows broad expression in FruM-expressing neurons in the adult male CNS.
Consistent with the Allen Brain Atlas, Plxna3 antisense probes indicated broad expression in SGNs in both the apical and basal regions of the cochlea.
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