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The FruMB isoform, like FruMC, shows broad expression in FruM-expressing neurons in the adult male CNS.
Tie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium.
Because Mesp1 broad expression in early gastrulating embryos suggests it could label mesodermal lineages other than cardiac23,24, data obtained with Mesp1 were confirmed with another cardiac-defining marker, Gata4 (Supplementary Fig. 2d).
Broad expression in clock cells resulted in unexpectedly long, robust periods (>28 hours) comparable to perturbation of core clock components, suggesting an unappreciated role of membrane dynamics in setting period.
Two receptors, OlfCa1 and OlfCc1, exhibited broad expression in a large fraction of neurons.
It is also evident that ifna1 has fairly broad expression in the tissues examined here.
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As such, BDNF may in fact enjoy a broader expression in OSNs over the lifetime of an animal.
Overall, we found generally broader expression in peripheral tissues as well as brain, consistent with a role in neuromuscular transmission.
Two other groups published similar findings using Cre transgenic mouse lines with broader expression in the retina [ 10] and throughout the CNS [ 11].
Our examination of public microarrays indicated that these young duplicates in clade I.1 contributed to the broadest expression in rice but to clade I.2 in Arabidopsis, in which the functional significance was unknown.
TLR7 and TLR9, the receptors for the viral PAMPs R-848 and CpG ODN, respectively, have a broader expression in the immune system than TLR3 and couple to the MyD88 rather than TRIF adapter protein.
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