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Few studies have found an effect for HDAC-inhibitors (HDAC-i) in urothelial cancer cell lines [ 12, 14- 17], however, a broad expression analysis of HDACs in urothelial carcinomas has not been conducted so far.
Despite the growth inhibitory effects of HDAC-i demonstrated in various cell lines including bladder cancer cells, a broad expression analysis of this attractive target has not been conducted yet [ 12- 16, 31, 32].
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Expression analysis of counted sequencing results reveals a broad range of patterns, as assessed by K-means clustering (Figure 3C and Figure S7).
Gene expression analysis of the transplanted cells.
Expression analysis of macrodactyly identifies pleiotrophin upregulation.
Expression analysis of Rs-cps in T2 generation transgenic plants.
Expression analysis of H3 and M1 constructs after overnight induction.
Supplementary Figure 7 Gene expression analysis of BAT and iWAT.
Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.
Importantly, combinatorial expression analysis of four identified targets predict patient outcome better than their individual analysis.
Fig. 4 Expression analysis of OsHox32.
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