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Conclusively, there is now consistent and broad evidence for a neuronal expression of the tumor suppressor merlin in both rodent and human tissue.
There is broad evidence for a polarization of caries prevalence and experience across different populations, with a decreasing percentage of (high-risk) patients showing an increasing number of carious teeth and treatment needs [ 1, 4, 30].
Although the importance of these dynamics to proper functioning of proteins is emerging in the studies of many protein families, there is a lack of broad evidence for the critical role of protein dynamics in shaping the biological functions of a substantial fraction of residues for a large number of proteins in the human proteome.
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We have a broad evidence base for the use of exercise and psychological therapies for treating CRF, but the effect sizes of these interventions tend to be small [20,21].
Taken together, our findings provide a broad evidence base for the role of aromatase in brain development relevant to reading, speech and language.
Given the broad evidence that dopamine is essential for attention and working memory [15] [18] and that the genetic polymorphism in the DAT gene is thought to be implicated in ADHD [31] [33], it is possible that both attention and working memory might play a role in pattern completion of memory retrieval under the partial-cue conditions through DAT-mediated dopamine regulation.
While these can be a useful tool for examining the broad evidence in relation to ABM, as with all meta-analyses, by combining the data of various studies critical distinctions can be missed.
These findings provide payers, health economists and clinicians with a broader evidence base for assessing potential benefits of the drug and may have important implications for both clinical and economic decision-making in mCRC.
The project not only enabled them to perform this task better, but also provided them opportunities to work in new ways and to get inputs from more sources to provide a broader evidence base for their materials.
Hence for this analysis, the VAP incidence proportion per 100 patients (VAP-IP) was also extracted and analysed in parallel to enable an assessment of comparability between the end points of SDD studies selected here which had B-IP data available versus the broader evidence base for which B-IP data was not available.
This paper also discusses the broader palaeoecological evidence for medieval landscape change across Northern Poland.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com