Sentence examples for broad epigenetic modifications from inspiring English sources

Other recent reports have revealed that Snail induces broad epigenetic modifications of target genes by interacting with tumor-associated proteins (including HDAC1, DNMT1 and p53) [ 7- 9].

Secondly, the genome undergoes broad epigenetic modification to a more PSC-like state, including demethylation of promoters for pluripotency-associated transcription factors such as Oct4 and Nanog and reactivation of the inactive X chromosome [ 60, 61].

Although DNA methylation is the most common epigenetic mechanism of mammalian genome regulation, it is only one component of a broad epigenetic program that includes other modifications of the chromatin.

However, MS suggests a broader view, with other features of the haplotypes, including epigenetic modifications, appearing to participate in important epistatic interactions.

Any outside stimulus that can be detected by the body has the potential to cause epigenetic modifications.

The way those genes are expressed is controlled through epigenetic modifications to the DNA, turning genes on and off and affecting how cells read genes.

Various diseases are related to epigenetic modifications.

Epigenetic modifications have been associated by many studies with several types of diseases and metabolic dysfunctions.

Epigenetic modifications control cell proliferation, differentiation, migration, and so on.

Epigenetic modifications have been proved to play a crucial role in complex chronic disorders [23, 24].

Also, these techniques often include amplification methods that remove the ability to detect epigenetic modifications.