Less studied, but prevalent in the human genome, are long regions continuously possessing a epigenetic modification ("broad modifications", [ 16, 22]).
It is thus surprising that histone clipping as a potential epigenetic modification continues to escape the attention of the broader scientific community, while it too can be identified by mass spectrometry 3, 70, 71, 92.
We use the term "broad modification" to denote long regions of chromosomal space in which there is a given epigenetic modification present continuously (>50 kb), as opposed to focal regions of modification ("peaks") in a promoter or other region.
Stress response constitutes another broad category of conserved age-related pathways that encompass a variety of biological processes, from immune regulation to epigenetic modification [12], [13], [14].
BPA seems to exert its effects through a number of mechanisms, including epigenetic modification.
Many unresolved X-Files cases that might be accounted for by a genetic mutation could just as easily be explained by an epigenetic modification of the same gene.
We tested whether Hdac6 influences epigenetic modification.
Another means of epigenetic modification is through microRNAs (miRNAs).
Human aging is associated with epigenetic modification of the genome.
The halogenation of DNA via radical species, particularly the formation of 5-chlorocytosine (ClC), has recently emerged as epigenetic modification.
DNMT inhibitor such as 5-azacytidne also plays a significant role in epigenetic modification.
