Sentence examples for broad epigenetic changes from inspiring English sources

These results suggest that some but not all regions are associated with changes in epigenetic signaling associated with differences in maternal care, with broad epigenetic changes apparent within both genic and inter-genic areas.

To index broad epigenetic changes observed across the locus, we defined a Regional Difference in DNA methylation and a Regional Difference H3K9 acetylation (RDme and RDac, respectively) as a statistically significant difference between High LG and Low LG offspring of at least 1000 bp containing at least one statistically significant probe per 1000 bp (see Methods S1 for details).

Two recently published studies have examined broad epigenetic changes in ovarian cancer[ 10, 11].

Our data suggests that histone variants, and thus broader epigenetic changes such as global changes in chromatin accessibility, may be an important component of the epigenetic mechanisms recruited at the first sensitive period during memory consolidation.

This compaction occurs through dramatic changes in the way the DNA is packed and falls under the broad banner of epigenetic changes in that it results in changes in chromatid structure that affect transcription.

Given the number of epigenetic regulators that contain CAF1p55, our findings raise the possibility that the oncogenic activation of BMI-1 may lead to a broad range of epigenetic changes that are not restricted to the function of BMI-1 as a PcG protein.

Increasingly, epigenome-wide approaches are useful in identifying a broader constellation of epigenetic changes associated with environmental exposures [ 50].

Targeting the mechanisms that produce these broad regions of epigenetic change represents a potential frontier for epigenetic targeted cancer therapies.

In this review, we paint a broad picture of current understanding of epigenetic changes in cancer cells and reflect on the immense clinical potential of emerging knowledge of epigenetics in the diagnosis, prognostic assessment, treatment, and screening of cancer.

Functional pathway analysis revealed that multiple epigenetic changes were identified within several broad, all-encompassing biological pathways.

Recent findings show that multiple cycle enzymes are either mutated or deregulated in a broad spectrum of cancer, resulting in characteristic metabolic and epigenetic changes that are correlated with disease transformation and progression.