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The doses of V presented in the study are within the broad dose range that was used for demonstrating the antidiabetic activity of V [ 19, 24] and for analysing its pharmacokinetic behaviour [ 25] on an animal model.
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In the present study, one noteworthy difference between the nicotine and the varenicline dose effect curves was the dose range that lowered ICSS thresholds.
In contrast, chlordiazepoxide, a benzodiazepine anxiolytic drug, which is an effective agonist at GABA-A receptors, did not produce signs of anxiolysis in zebrafish over a broad dose range up to those that caused sedation.
It should be noted that while the dose-response curve for DNA adducts is generally linear, it does not follow that dose-response curves for gene mutations or chromosomal mutations are linear over a broad dose range (Swenberg et al., 2008).
These doses were chosen to permit an evaluation of multiple biodosimetric assays over a broad dose range.
The derived estimates were based on a large and homogeneous cohort with a broad dose range.
In our example, it became apparent that the design was similar in structure to the fixed parameter design, but the number of dose levels was increased and covered a slightly broader dose range.
In contrast, a broader dose range of I'm-Yunity™ (PSP) affects the expression of the p65 subunit.
Further studies are needed to confirm the reinforcing effects in broader dose ranges with various schedules.
This is a very broad range that contains a tedious amount of discussion.
Two patients had values that fell within the broad normal range that we established (mean ± 2SD).
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CEO of Professional Science Editing for Scientists @ prosciediting.com