Sentence examples for broad dose range from inspiring English sources

In studies designed to explore this general response over a broad dose range, female Swiss mice were administered six different diets containing Pb acetate 1 day after mating.

Effects of subcutaneous administration of two selective melanin-concentrating hormone MCH1 receptor antagonists, labeled A and B were examined over a broad dose range (1, 3, 10, 20, 40 mg/kg) on rat sleep wake architecture.

In contrast, chlordiazepoxide, a benzodiazepine anxiolytic drug, which is an effective agonist at GABA-A receptors, did not produce signs of anxiolysis in zebrafish over a broad dose range up to those that caused sedation.

The 2 aforementioned institutions all infused CAR-T cells at a relatively broad dose range, while a fixed dose of either 1 × 106 or 3 × 106 CAR-T cells/kg was employed in a phase I dose escalation study (NCT01593696) performed at the NCI to investigate anti-CD19 28ζ CAR-T cells for children and young adults with R/R B-ALL (Lee et al., 2015a).

These doses were chosen to permit an evaluation of multiple biodosimetric assays over a broad dose range.

The derived estimates were based on a large and homogeneous cohort with a broad dose range.

In contrast, a broader dose range of I'm-Yunity™ (PSP) affects the expression of the p65 subunit.

In our example, it became apparent that the design was similar in structure to the fixed parameter design, but the number of dose levels was increased and covered a slightly broader dose range.

At the end of phase IIa, it would also be relevant to include patient data from phase I trials, and at submission it would be relevant to include, both the larger phase III and the phase IIb dose-finding trials, which typically span a broader dose range.

Further studies are needed to confirm the reinforcing effects in broader dose ranges with various schedules.

In order to investigate the high resolution capability of nitrocellulose resist, periodic line array with a period of 600 nm was exposed at 20 keV over a broad line dose range and subsequently coated with 30 nm Cr for SEM imaging.