These gradients instruct, in a concentration dependent manner, broad domains of expression of early zygotic genes, the 'gap genes' (Chen et al., 2012).
The grouping of genes into broad domains of expression had predictive power, as shown by the correct assignment of genes with know expression patterns and the results of in situ hybridizations performed on candidate genes.
An essential, conserved characteristic of proneural genes is their ability to restrict their own activity to single or a small number of progenitor cells from their initially broad domains of expression.
Anthox6a shows the broadest domain of expression, extending across approximately 2/3 of the dorso-ventral axis (Figure 5E).
Between E4 and E5 (st.24-st.27 st.24-st.27Fin. 1G), this broad domain of Atoh1 expression is refined to the rostral pole of the chickellar primordium.
The e nc1 expression in the outgrowing tail bud is found in a broad domain of mesenchyme (fig. 6 A").
The broad domain of education also significantly relates to AOD use during adolescence (Crosnoe 2011).
It is worth noting that the severe Nv eve anterior defects are more regional, as observed for Oncopeltus eve that behaves as a gap gene, and is attributed to the broad early domain of expression (Liu and Kaufman, 2005a).
Expression of the PIN1 auxin efflux protein [ 27, 35] is initiated in broad domains of leaf inner cells that become gradually restricted to files of vascular precursor cells in contact with pre-existing, narrow PIN1 expression domains [ 33, 36– 42].
Broad domains of lamins (LADs), H3K9me3 and H3K27me3 were called using the enriched domain detector (EDD) for identification of wide genomic enrichment domains68.
