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Mesenchymal stem cells (MSCs) have a broad differentiation potential.
It can be processed easily to yield large amounts of epithelial and mesenchymal cells that have shown broad differentiation potential.
CNCCs are a transient embryonic cell group which delaminates from the neural tube, migrates long distances and acquires an extraordinarily broad differentiation potential, ultimately giving rise to most of the craniofacial structures and determining their individual and species-specific variation.
Cells and tissues derived from such cultures may provide the unique advantage of possessing a large replicative capacity and broad differentiation potential.
Although it was our initial intention to produce a progenitor cell population with broad differentiation potential into all mesodermally-derived tissues, we made the surprising finding that the differentiation potential of these IMP cells was restricted to the IM lineage.
When injected into immune-compromised mice, ORMES-9 gave rise to cell lineages representative of all three embryonic germ layers, further demonstrating its broad differentiation potential (Supplementary Data, Fig. S2C).
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Further strictly controlled, side-by-side comparisons between the two types of stem cells also showed that the expression patterns of gene markers and the broad differentiation potentials induced by specific methods in vitro were very similar.
Adult stem cells display a broader differentiation potential than anticipated and might contribute to tissues other than those in which they reside.
Since these are already committed to certain lineages, the question remains whether adult tissues also harbor other stem cells with much broader differentiation potential across germ layers that are multi- or pluripotent.
Besides these factors, MSCs display a broader differentiation potential.
Thus, SS likely originates from MSCs, which demonstrate a much broader differentiation potential than do SS cells, including endothelial differentiation; this view supports the findings in previous reports.
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