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Surprisingly, broad differences in gene expression patterns were observed.
For example, the two congeneric oyster species Crassostrea virginica and C. gigas, both lacking DUI [ 28], show broad differences in gene content and gene order with relocation of most tRNA genes [ 2, 40].
An initial analysis comparing animals with rejection (allograft recipients; BN rats) to those without rejection (isograft recipients; DA rats) indicated broad differences in gene expression and the possibility of multiple, strong biomarkers that could distinguish these phenotypes.
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Obviously, there are broad differences in CYP450 gene expression between hESC-derived hepatocyte-like cells generated in different studies.
We observed a broad epigenomic response associated with an extensive difference in gene expression.
Beyond sulfur metabolism, the two copper extremes exhibited broad differences in expression profiles of genes involved in amino acid biosynthesis, oxidative stress, and cellular respiration.
There are, however, broad differences in approach between Wolf and Rafman.
Differences in replication timing could be a consequence of local or broad differences in chromatin structure.
We next examined the localization of broad differences in H3K9 acetylation, DNA methylation (i.e., RDac and RDme) and transcription with respect to the physical anatomy of genes within the locus.
There are broad differences in the midgut epithelial responses to Plasmodium invasion between An. gambiae strains.
In addition, we observed broad differences in sequence-level conservation of DBD ortholog pairs within families.
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