Sentence examples for broad defects in from inspiring English sources
Thus, while rsp5 mutant strains exhibit broad defects in the heat-induced endocytic response, Δart1 mutant cells are defective for the turnover of only a subset of PM proteins.
These mutants show a variety of phenotypes, from broad defects in many sensory modalities to defects in the response to a single odorant [13].
Endocrine progenitor cells lacking Insm1 were less differentiated and exhibited broad defects in hormone production, cell proliferation and cell migration.
In vivo, the absence of Get1/Get2 leads to cytosolic aggregation of Get3-TA complexes and broad defects in TA protein biogenesis.
Large perturbations in the Spt6- Pob3 interaction would most likely lead to more broad defects in cell growth and DNA replication/repair, which were not detected in these mutants by our phenotypic assays.
Although eliminating a single modification does not have a dramatic effect on the ribosome [ 44], loss of three to five modifications in an intersubunit bridge of the ribosome (helix 69) impairs growth and causes broad defects in ribosome biogenesis and activity [ 45].
Treg deficiency caused by the ablation of PP4 is fairly broad, encompassing defects in nTreg/iTreg differentiation, suppressor functions and gut homeostasis.
Thus, a broad defect in secretory pathway TA protein insertion could fully account for the diverse phenotypes observed upon loss of the Get1/Get2 receptor.
These mechanisms include reduced production in persisters of reactive oxygen species (ROS) influenced by the levels of antioxidant enzymes, inhibition of macromolecule synthesis by toxin antitoxin (TA) modules, increased suppression of cellular metabolism mediated by PhoU and the presence of defects in trans-translation pathway that confer a broad defect in MDT.
Even though D0264, D0067, and D0177 were isolated for defective LTM in an olfactory paradigm, they display distinct behaviors in the optomotor maze, suggesting broader defects in short-term behavioral processes.
This is attributed to the implant-induced damage, which is observed as a broad defect peak in photoluminescence (PL) prior to any annealing.
