Sentence examples for broad clinical application of from inspiring English sources

However, broad clinical application of gene therapy is currently hindered by the need for safer and more efficient delivery vectors.

With few exceptions, where local administration is feasible, progress towards broad clinical application of gene therapies requires the development of effective delivery systems.

However, multiple barriers exist to the broad clinical application of xenotransplantation, including immunologically mediated graft rejection of xenogeneic tissues, metabolic or molecular incompatibilities between donor organs and humans, ethical concerns, and the risk of infections that may be transmitted from donor species to humans.

The low efficiency of genetic transposition is a major obstacle preventing the broad clinical application of this method; however, the low cost, convenient manufacturing, and mild toxicity of this system render it attractive as an alternative treatment strategy (Kebriaei et al., 2016).

Today, however, broad clinical application of such inhibitors is precluded by the lack of mechanistic insights.

The broad clinical application of p27 in the prognostic evaluation of breast cancer will require the development of a consensus on methods of tumor fixation staining and scoring.

Broad clinical applications of BsAb have been, and still are, significantly hampered by the difficulty in producing the materials in sufficient quantity and quality by traditional approaches.

Muin J Khoury, Section editor, Genomic epidemiology and public health genomicsa In recent years, the personalized approach of pharmacogenomics-guided treatment has been acclaimed as one of the most promising innovative concepts in medicine and one of the first broad clinical applications of genomic medicine.

As the key challenges of T-cell avidity, persistence and ability to exert the desired anti-tumour effects as well as the identification of new target antigens are addressed, a broader clinical application of these therapies could be achieved.

Broad clinical application, however, requires availability of a tre-recombinase that recognizes a majority of clinical HIV-1 isolates.

Currently we are witnessing an era in which molecular diagnostics utilising nucleic acids are reliable enough for use in patient care and for broad clinical application; however, despite the tremendous number of potential biomarkers found using high-throughput genomic methods, only a few have been vigorously validated and are used for clinical diagnosis.