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This systems level understanding should have broad clinical benefits.
Therefore, the triple combination of PARPi, chemotherapy and RIT may have broad clinical utility.
Similarly, broad clinical adoption would likely require timely and secure fixation through an arthroscopic surgical approach.
However, to date there has been no proven technique effective for broad clinical application.
Therefore, svOCT may have broad clinical applications in the study of human retinal physiology and disease.
Meanwhile total ankle arthroplasty is in a broad clinical use and has lost its experimental character.
Given the low spatial resolution and limited signal-to-noise ratio, a broad clinical application appears to be difficult.
However, broad clinical application of gene therapy is currently hindered by the need for safer and more efficient delivery vectors.
Spinal muscular atrophy (SMA) is a neurodegenerative disorder showing a broad clinical spectrum and no cure to date.
Lack of safe and effective carriers for delivery of RNA therapeutics remains a barrier to its broad clinical application.
Nevertheless, results of larger controlled trials are needed, before recommendation for a broad clinical application can be made.
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