Sentence examples for broad changes in dna from inspiring English sources

In contrast to the K27M mutation, broad changes in DNA methylation and histone marks underlying G34R/V induced tumorigenesis are less clear.

This study [ 81] revealed broad changes in DNA methylation that included both hypomethylation and hypermethylation, and measured their association with gene expression and copy number variation.

Broad changes in DNA methylation, particularly at the aryl hydrocarbon receptor repressor (AHRR) locus, occur in samples from subjects with long histories of smoking.

Our data reveal that PB-induced transcriptional perturbations are not generally associated with broad changes in the DNA methylation status at proximal promoters and suggest that the drug-inducible CAR pathway regulates an epigenetic switch from repressive to active chromatin at the target gene Cyp2b10.

Compatible host-virus interactions result in systemic infections that trigger broad changes in gene expression [ 49].

In conclusion, in a pilot study of relatively healthy subjects entering and exiting 30 day inpatient alcohol treatment, we show that high levels of recent alcohol consumption are associated with broad genome-wide changes in DNA methylation and that these changes tend to partially revert after several weeks of abstinence.

"There's been a broad change in the security environment".

Because DNA methylation is correlated with histone modifications and chromatin states, it may become possible to use DNA methylation as a surrogate for inferring broader changes in epigenomic cell states.

But clearly broader changes in the culture accelerated the shift.

In order to characterize the broader changes in secondary metabolism, we undertook a detailed metabolomics study.

Epigenetic alterations are heritable changes in gene expression that occur without changes in DNA sequence, with the broadest definition including all factors other than DNA sequence changes that heritably influence gene expression (Berger et al. 2009).