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Despite JPMorgan's relatively more stable businesses, Moody's Investors Service cut the bank's ratings Thursday to double-A-3 from double-A-2, citing the "poor prospect" of Morgan generating capital in the current recession as well as "broad challenges," including higher loan loss reserving and asset value deterioration.
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Critics say Mr. Gauck is too focused on democracy at a time when Germany faces broader challenges, including its growing role in Europe, where expectations are often coupled with skepticism over whether the country is up to the job.
Broader challenges include accounting for benthic and pelagic coupling, resolving how climate change will alter pelagic processes, and demonstrating the likely effectiveness of spatial management given the large movements of many pelagic species [15].
Nevertheless many financial directors could benefit from a more holistic view of how broad sustainability challenges, including climate change and the steep rise in price of the world's natural resources, present enormous risks to business.
The PC teams in this study have demonstrated their value as they address broad health care challenges, including issues related to quality through the provision of holistic and patient-centred care, as well as working with primary care providers in building capacity for end-of-life care.
All specialists involved in the care of an individual with Pompe should have an understanding of the disease, its broad and protean manifestations, and challenges, including the psychological and emotional impact of this devastating disease on patients and families.
Clinically, affected individuals face a broad range of intellectual and physical challenges, including IQ scores ranging between 20 and 70, mild abnormal facial features and macroorchidism in prepubescent males[2].
Identity management is a broad domain that involves many open security issues and challenges including Openness, Identity Theft, Least Privileges, Elevated Privilege Control, Availability, Confidentiality, Integrity, Trust Management etc (Cloud Security Alliance SecaaS Guidance, Category 1: Identity and Access Management, 2012 by Cloud Security Alliance 2013).
There has been important progress made to overcome these challenges, including the development of enzymes with broader substrate scope and the design of methodology to effectively displace the reaction equilibrium.
The utility of MRI for assessing adipose tissue has been recognized for some time, but the low sensitivity and technical challenges including long scan duration have limited its broader utilization.
Despite significant advances, the future study still holds challenges including lack of predictive biomarkers, non-specificity of broad-spectrum histone acetylation drugs, and ambiguous mechanisms for therapeutic response/resistance [ 99].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com