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Interestingly, the application of a mixed immunization combining both clades (B and BF) induced a broad cellular response, in which the majority of the peptides targeted after the single clade vaccinations generated a positive response.
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Significantly, application of a mixed immunization combining both clades (B and BF) induced a broader cellular response, in which the majority of the peptides targeted after the single clade vaccinations generated a positive response.
Cytochrome P450 enzymes may therefore be part of a broader cellular response that has previously been associated with longevity in long-lived and CR mice [ 59].
Decreased blood flow during ischemia activates the synthesis of various genes and proteins that regulate the ischemic process and/or are involved in the broader cellular response, depending on the extent of the injury.
This finding suggests that HA-expressing live viral vectors are capable of triggering a strong and very broad cellular immune response against influenza viruses of different clades.
The highest degree of protection from weight loss was seen in those animals with both protective antibodies and broad cellular immune responses, losing 10.6% body weight ±3.4% (compared to 24.7%±1.5% in the control group, p<.05).
This review summarizes the current rationale and status of clinical and experimental HCV vaccine candidates based on the elicitation of cross-neutralizing antibodies and broad cellular immune responses to this highly diverse virus.
Today, IFN is known as a key component of the innate immune system responsible not only for broad cellular antimicrobial activity in response to primary infection, but also for its role in linking innate and adaptive immune responses (Biron 2001).
Chimeric proteins carrying epitopes, or adjuvant sequences increase the possibility of eliciting a broad cellular or humoral immune response.
An efficient vaccine against HCV infection requires induction of broad cellular and humoral immune responses against several viral proteins.
Interestingly, this analysis revealed that three of our patients had broader cellular immune responses against the minimal optimal epitopes than against the 15-mer HIV-1 type B consensus peptide set in ELISPOT-IFN-γ assays.
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