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Broad cellular processes were targeted, with the most enriched disease category for both truncation variants being Cancer.
To gain further insight into mechanism of selective CSC targeting by G2.2, we examined its effect on broad cellular processes in spheroid cells.
It is possible that alteration of proteins such as transcription factors or receptors that affect expression of many downstream genes and broad cellular processes may result in different phenotypic outcomes.
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We excluded genes such as AKT involved in broad-acting cellular processes e.g. cell signalling and growth factors.
This may have occurred in cases where broad-acting cellular processes are represented in the gene sets.
Reversible protein phosphorylation is implicated in the regulation of a broad range of cellular processes.
Proteins within this family harness the chemical energy of ATP hydrolysis to perform a broad range of cellular processes.
These methods allow researchers to regulate protein activity with exquisite spatiotemporal control, and open up new possibilities for studying the roles of proteins in a broad array of cellular processes and biological functions.
Although classically characterized as directors of cellular migration, chemokines have since have been shown to be involved in a broad range of cellular processes [15], [16], [19].
Ubiquitination is a major player in regulating a broad range of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control [24], [25].
They are important cytoskeletal proteins involved in a broad range of cellular processes, from movement to cell division [61], [62], [63].
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