The broad resistance to cell death, occurring upon the intracellular balance of the Bax/Bcl2, Bax/Bclxl, Bak/Bcl2 and Bak/Bclxl ratios, have potential relevance for cell behavior including cell invasion, adhesion, or metastatic potential [ 29].
However, it is apparent that KSHV carries a broad anti-cell death repertoire, which may provide relevant targets for anti-viral therapy strategies.
The GO classifications were further grouped into twelve broad categories as follows: Cell death and apoptosis (death, GO 0016265; cell death GO 0008219; apoptosis GO 0006915).
In addition to the broad categories of energetics and cell death, metabolites of Vitamin B6 are altered by heat stress (Additional file 8).
From a broader perspective, the dysregulation of cell death is at the center of essentially every form of liver disease.
The photoinitiator 2-hydroxy-1-[4- hydroxyethoxy phenyl]-2-methyl-1-propanone (Irgacure 2-hydroxy-1-[4- hydroxyethoxy phenyl]-2-methyl-1-propanonenge 2-hydroxy-1-[4- hydroxyethoxy phenyl]-2-methyl-1-propanone
NRIP1 is a regulator of nuclear receptors that have broad functions in regulating cell growth, cell death, and metabolism.
TAT-NBI1 is able to induce cell death in a broad panel of cancer cell lines (Supplementary Figure S1 and Table S2).
It was found that the highly substituted titanocenes are as effective as cisplatin at inducing cell death against a broad range of human tumours, and in some cases, titanocenes displayed greater cytotoxicity than cisplatin.
By contrast, if migration is high, tumour size advances for a broad range of proliferation capacities and cell death rates, with both exerting counterintuitive long-term effects on the migration-enabled growth.
