Exact(5)
Generally, chimps had relatively short and broad brain proportions, whereas humans had long and narrower proportions.
I see the Perelmans in their catalog and I'm transported to Cloudland and broad brain smiles.
In situ hybridization revealed that kakusei expression can be detected in every brain region, including the MBs, optic lobes (OLs), and antennal lobes (ALs) in a seizure induction-dependent manner (Figure 2C J), suggesting that kakusei can be used as a marker in broad brain regions.
The use of cell-type promoters, such as tyrosine hydroxylase, is a limitation to transgenic overexpression that prevents the induction of the broad brain pathology observed in humans.
Intensive investigation of a single VPSPr case showed broad brain region-specific spectrum of protease sensitivity, differing relative amounts of ~8 kDa PrPres and ~19 & 23 kDa PrPres, and the stability of PrPSc in the absence of proteases depending on the brain region examined.
Similar(55)
And consensus has been growing that researchers should focus not on individual mutations but the broader brain circuits that those mutations affect, says Luca Santarelli of Roche, a Swiss drugs firm.
However, higher density microelectrode recording arrays of larger area are needed to study neuronal function over broader brain regions such as in cerebral cortex or hippocampal slices.
Accordingly, >40% of the products of HVC markers (as compared to 21% for the broader brain collection) localize to the plasma membrane, and a majority have receptor, ion channel, calcium ion binding, and G-protein signaling activities (Fig. 4B).
This apparent contradiction may be attributed to methodological differences, as imaging studies usually sample a broader brain area and do not exclude circuit-dependent inductions during measurement, whereas molecular studies are more localized.
This is consistent with that, comparing with broader brain functions mediated by syn-NMDAR, ex-NMDAR has limited roles.
In addition, we used the mouse prion promoter, which drives high transgene expression in mouse neurons (Baybutt and Manson, 1997; Loftus et al., 2002; Gispert et al., 2003), to express the transgene in a broader brain area.
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