Sentence examples for broad biological function from inspiring English sources
While such knowledge contributed immensely to the strength of the comparative functional genomics paradigm, understanding the broad biological function of transcription factors in an evolutionary context is not complete without a systematic investigation of the contribution of upstream sequence variation to the potentially unique regulatory features of each member of an orthologous group.
We were able to identify transcriptional modules that appear to be robust and for which broad biological function could be assigned to.
However, similarities in expression are punctuated by changes in other features that serve to fine-tune physiological functions in the divergent species, while maintaining the broad biological function of the gene.
Patterns of cis-regulatory conservation imply that each ortholog has distinct signatures, further suggesting that they are potentially unique in a regulatory context despite the presumed conservation of broad biological function during speciation.
Overall, the resolution afforded by the analysis of tri-species COGs revealed a general trend in which orthologous stress-associated bZIP transcription factors of rice, sorghum and Arabidopsis have finer-scale differences in regulatory information content, both qualitatively and quantitatively, despite the presumed conservation of broad biological function (i.e., stress response).
Catechol- O-methyltransferase (COMT) enzyme has broad biological functions, principally the catabolism of biologically active or toxic catechols, including catecholamines and catecholestrogens [ 1].
Sirt1 is one of sirtuin family proteins which are conserved NAD+-dependent histone deacetylases with broad biological functions [49], [50].
The physiological role of DJ-1 implicates broad biological functions including modulation of transcription, chaperone-like functions and antioxidant properties [9].
CA125 serum levels are also elevated in some benign conditions and other carcinomas [1], raising the possibility that MUC16 might have broad biological functions.
This study highlights that DNA damage, specifically, is the trigger for the modulation of transcripts that encode proteins with broad biological functions.
