These have broad binding specificity as they bind IGF-1, IGF-2, and also insulin [ 119].
U2AF65 has a broad binding specificity for motifs comprising both uridines and cytidines, leading to recognition of a very heterogeneous spectrum of polypyrimidine tracts (Singh et al., 2000).
It is thus speculated that LukS-PV signal peptide behaves like Eap (extracellular adherence protein, also known as Map and p70), an adhesin with broad binding specificity but with particular affinity for the extracellular matrix and plasma proteins, which binds to the S. aureus cell wall by a sortase-independent mechanism.
The chemical diversity of the previously identified ligands raises fundamental questions about the structural basis for RKIP ligand interactions: Does the pocket have an extremely broad binding specificity so that it can bind to all of these ligands?
From these structures and a saccharide-binding analysis of the N46A mutant, we revealed that a conformational change of a unique insertion sequence containing Asn46 provides two binding modes for ACG, and thereby confers broad binding specificity.
Numerical analysis of reaction time courses showed that CelEcc_CBM44, a combination of a multifunctional enzyme domain with a CBM having broad binding specificity, gave the fastest rates for hydrolysis of both the hexose and pentose fractions of ionic-liquid pretreated switchgrass.
Analysis of the structural features of the NA hemadsorption site (Fig. 5) explains the inability of the hemadsorption site to differentiate between the 6- and 3-linked sialic acids and predicts that this site can have a relatively broad binding specificity.
A fungal galectin from Agrocybe cylindracea (ACG) exhibits broad binding specificity for β-galactose containing glycans.
Fibronectin is an extracellular matrix protein with broad binding specificity to cell surface receptors, integrins.
This broad binding specificity may be important for dSfmbt function within the PhoRC complex.
