In the 10 years since James Thomson's discovery, scientists have shown that embryonic stem cells have the potential to help create replacement cells for a broad array of tissues and organs, including the heart, liver and pancreas.
Embryonic stem cells, it declared, are "capable of becoming almost all of the specialized cells of the body and, thus, may have the potential to generate replacement cells for a broad array of tissues and organs, such as the heart, the pancreas, and the nervous system".
In zebrafish, three homologous meprins, two meprin α variants and one β, are expressed in a broad array of tissues.
With this approach in common marmosets (Callithrix jacchus) and cotton-top tamarins (Saguinus oedipus), chimerism was detected across a broad array of tissues.
It is also possible that mutations at third codon positions in genes expressed in female organs and gametes may on average have greater effects on fitness, as has been proposed for genes expressed across a broad array of tissues (higher selection coefficients) [ 8, 9].
Given the established consequences of sleep deprivation on the immune [ 12, 13, 23],cardiovascular [ 12, 24], metabolic [ 9, 11, 25, 26] and musculoskeletal function [ 27], It is reasonable to suspect that sleep state impacts a broad array of peripheral tissues.
Several RBPs that affect the turnover and translation of proteins implicated in proliferation, survival, inflammation, neurodegeneration, and cancer (HuR, AUF1, TIA-1, TTP) displayed elevated abundance in a broad array of human tissues and in all ages, suggesting that their influence extends throughout the human life span [ 100].
Thus, embryonic stem cells appear to have unique potential to lend themselves to a broad array of disease therapies, creating new healthy tissue to replace damaged or dead tissue, such as pancreatic islet cells for Type 1 diabetes, or various neuronal cells for spinal-cord injuries, A.L.S., and Parkinson's disease.
Porphyromonas gingivalis produces a broad array of potential virulence factors involved in tissue colonization and destruction as well as host defense perturbation.
A further confounding factor has been the heterogeneity of phenotypes with studies examining genotypes with breast, prostate or colorectal cancers although it is now recognised that each of these may represent a broad array of cancers that affect the same tissue and that genes may have different effects on the initiation and progression of these different diseases.
