This broad array of response signaling triggered the p53-dependent pathway to execute and complete cellular apoptosis.
By contrast, there may be a more general reprogramming caused by EDCs, such that exposed individuals and their offspring have altered responses to environmental (proximate) stimuli that go beyond a single system (e.g., estrogenic EDCs) and affect a broader array of responses, including stress responsiveness, as we use as an example below.
"I think it has broad appeal, but I've borne witness to a wide array of responses," he said.
He had started out as a vaudeville hoofer, and like many vaudevillians, learned to do everything: he could dance, carry a tune, tell jokes, ad lib, read lines and contort his handsome rubbery face into a broad array of clownish responses.
Likewise, a broad array of polyfunctional responses to these peptides was detected using DC as APC (P<0.02 compared to No DC) (Fig. 8C, DC).
For most drugs, a large sample size and a substantial length of follow-up for exposed and unexposed patients allowed the conduct of a broad array of dose-response relation analyses and sensitivity analyses, each of which supported the primary conclusions.
The current version of RuphiBase appears to offer already a good representation of the clam transcriptome, as shown by the broad array of potential markers of response to xenobiotics.
In contrast, with DC, a broad array of monofunctional and polyfunctional responses were induced in CD8+ T cells by p24165 179 (P = 0.01 compared to p24161 175) and p24169 183 (P = 0.07 compared to p24161 175) (Fig. 8A, DC).
IL-10 is a pleiotropic cytokine produced by a variety of immune cells (e.g. TH2 cells, macrophages and CD8+ cells) that can inhibit a broad array of immune and inflammatory responses.
Until that day arrives, clinicians utilize rather blunt tools designed to suppress a broad array of the members of the inflammatory response, such as methotrexate and corticosteroids or more targeted monoclonal antibodies to effecter proteins like TNF (tumor necrosis factor).
