The last mass spectrometry technology used is LC-MS (Liquid Chromatography), which allows the analysis of a broader array of molecules.
The receptors there are a hundred times denser than in a human, and can detect a wide array of molecules.
Finally, the method for incorporating biological functionality into the material should be applicable to a broad array of bioactive molecules, from small molecules to peptides to proteins.
The ligands are called pathogen associated molecular patterns (PAMPs) and include a broad array of microbial molecules build-up of proteins, nucleic acids, lipids, or synthetic chemicals.
A broad array of adhesion molecules, such as carbohydrates, lectins, selectins, cadherins, integrins, have been implicated in the adhesion of tumor cells to the BECs (Miles et al. 2008).
Briefly, a broad array of small molecule metabolites, irrespective of class (e.g., amino acids, lipids, carbohydrates), was examined to measure biochemical changes within plasma samples collected after an overnight (10 12 hours) fast.
In most cell types, the detection of PAMPs by their respective TLR evokes a potent pro-inflammatory response, involving rapid induction of myeloid-differentiation factor 88 (MyD88) and NF-κB-dependent signalling pathways, and the resultant expression of a broad array of pro-inflammatory adhesion molecules, chemokines and cytokines.
Rather, effective cytotoxicity associated with immunologic control may be mediated through a broad array of epitopes and HLA molecules.
The finding that 75% of the patients in the intermediate dose group developed a T-cell response to the vaccine supports the notion that GV1001 contains binding motifs that allows promiscuous binding to a broad array of HLA class II molecules.
These mature brain endothelial cells also express a broad array of large and small molecule transport systems including nutrient influx transporters and efflux transporters such as p-glycoprotein (p-gp), multi-drug resistance-associated proteins (MRP), and breast cancer resistance protein (BCRP) (for a review, see [ 27]).
