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Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubiquitous ion channels responsible for cytosolic Ca(2+) signalling and essential for a broad array of cellular processes ranging from contraction to secretion, and from proliferation to cell death.
These methods allow researchers to regulate protein activity with exquisite spatiotemporal control, and open up new possibilities for studying the roles of proteins in a broad array of cellular processes and biological functions.
Using this significance threshold, 127 proteins (82 up-regulated, 45 down-regulated) representing a broad array of cellular functions showed changes in abundance.
Collectively, PP2A holoenzymes target a broad array of cellular phosphoproteins.
DCHF-DA was used to assess the presence of a broad array of cellular ROS levels, as previously described.
Even more remarkable is the broad array of cellular networks that intramembrane proteases have come to regulate.
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Protein kinases transduce signals to regulate a wide array of cellular functions in eukaryotes.
Recent evidence has shown that in Saccharomyces cerevisiae HSF directly activates the expression of genes whose protein products are involved in protein folding and degradation, ion transport, signal transduction, energy generation, carbohydrate metabolism, vesicular transport, cytoskeleton formation, and a broad array of other cellular functions (Hahn et al. 2004).
These interactions, together with other proteins that bind to HPV16, alter a broad array of cell cycle progression; for example, they block cellular proliferation by causing cell cycle arrest in S-phase [ 12, 50, 51].
This broad array of eukaryotic hosts that support FHV RNA replication suggests that cellular factors utilized by this virus are widely conserved.
A smartphone is a cellular telephone with an integrated computer that is capable of performing a broad array of tasks, including running various downloadable applications (apps) that typically are not associated with a cellular phone.
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