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This approach was based on the concept that we could sample a broad array of activation pathways and, thereby, develop a general profile of immune responsiveness rather than define the responsiveness of specific innate or adaptive immune pathways.
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Leisure includes a broad array of activities, such as sport, tourism, and the playing of games.
Tilorone, is an investigational antiviral agent that has shown a broad array of biological activities including cell growth inhibition in cancer cells, antifibrotic properties, α7 nicotinic receptor agonist activity, radioprotective activity and activation of hypoxia inducible factor-1.
Epiphora can affect a broad array of daily activities.
--And these jobs come in a very broad array of industries and activities.
Patients with musculoskeletal conditions reported a broad array of perceived physical activity barriers and facilitators.
Multiple copies of C2 domains have been identified in a growing number of eukaryotic signalling proteins that interact with cellular membranes and mediate a broad array of critical processes, including membrane trafficking, activation of GTPase for vesicular trafficking, control of protein phosphorylation and generation of lipid second messenger involved in signal transduction [ 81, 82].
Ras-GTPases are potential candidates that can transduce the constitutive and concurrent activation of a broad array of effectors such as ERK and AKT.
HMGA1-dependent activation of Akt signalling is likely to protect cancer cells from broad array of proapoptotic stimuli, not just those related to anchorage deprivation.
Taken together, these results support a model where a broad array of antigens support the generation of diverse DEM CD4 T cells in the context of the innate immune activation milieu that persists in chronically HIV-1 infected individuals.
In these situations, cellular recognition of the challenge results in activation of the nuclear factor erythroid-derived 2-like-2 (Nrf2) pathway, which regulates a broad array of cytoprotective, antioxidant, drug metabolism and bioenergetic systems [ 5– 7].
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