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We observed that the duration of renal failure is prolonged in critically ill patients randomised to receive high exposure to broad-spectrum antibiotics and escalated diagnostic work-up according to a biomarker-strategy compared with patients randomised to receive standard care according to guidelines regarding use of antibiotics and diagnostics.
"But these last couple of months it's just been escalating and escalating and escalating.
Within 24 hours of starting broad spectrum antibacterial agents for new onset febrile neutropenia, micafungin was initiated at 0.5 mg/kg/day and escalated to a maximum of 4 mg/kg/day.
"Then it just escalated and escalated".
Everything had just escalated and escalated.
"It would escalate and escalate, and then she's hyperventilating.
"It just continued and it just escalated and escalated.
But the feud between the two men escalated and escalated.
Since then we have just watched it escalate and escalate.
Provisional IRA Chief of Staff Seán Mac Stíofáin decided they would "escalate, escalate and escalate" until the British agreed to go.
Subsequently, OXA was added and escalated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com