The proteasome has relatively broad activity divided into three main classes – chymotrypsin-like, trypsin-like and peptidlyglutamyl peptide hydrolysing (Heinemeyer et al., 1997).
In the field of antineoplastic chemotherapy, taxanes (paclitaxel and docetaxel) represent an important class of compounds, with broad activity in solid tumours (Rowinsky, 1997).
Trichostatin A (TSA) belongs to the class of histone deacetylase inhibitors that have broad activity spectra.
Thiazolides are a novel class of anti-infectious drugs used for the treatment of intestinal infection, and show a broad activity against intestinal pathogens.
Trichostatin A (TSA) is an HDAC inhibitor [9] that shows broad-spectrum activity against class I and class II HDACs.
Therefore, NA inhibitors which mimic SA structure in its transition state during NA catalyzed hydrolysis, represent a class of anti-influenza drugs with broad activities against different influenza virus strains.
1,2,4-Triazole, an important class of heterocyclic rings, has attracted increasing attention due to their broad activities, such as fungicidal [1, 2], insecticidal [3, 4], herbicidal [5, 6], and bactericidal [7, 8].
CAC = ChEMBL activity class.
Ideally, the next generation of treatments for nosocomial and community-acquired infections, including those caused by Candida spp, Aspergillus spp, Cryptococcus spp and Fusarium spp, will be more efficacious, with higher therapeutic indices and broader activity spectra than existing antifungal drug classes.
Three broad classes of activity spaces that are outside formal learning contexts include play; interests and hobbies; and communication, self-expression, and identity.
