Sentence examples for broad actions of from inspiring English sources

Although physiology-based approaches have been highly successful at defining the broad actions of these receptors, much of the detail in terms of how regulation is exerted has still to be defined.

Thus, there is a lack of regional or neuronal subtype specificity in the binding and effects of patient antibodies, suggesting broad actions of anti-NMDAR antibodies on cell types across brain regions.

The increase of Aβ in aged Sort1−/− mice could be explained by the broad actions of sortilin, acting not only as a receptor for proNGF but also for neurotensin [20] and progranulin [21], both of which are suggested to play a neuroprotective role [22,23].

More specifically JAK3 mediates signaling through the common gamma chain of IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 cytokine receptor complexes, explaining the broad action of tofacitinib.

This is due to the broad action of proteins involved in chromatin and epigenetic regulation of gene expression.

Nitrous oxide has broad actions, including inhibition of NMDA glutamate receptors, stimulation of opioidergic and GABAergic transmission and possibly via imitation of nitric oxide (Emmanouil and Quock, 2007).

These results support their broad physiological actions of 1 α,25(OH)2D3 in a variety of cell types.

Thus, the promising application of clinical approaches based on TGF-β1 targeting for breast cancer treatment may be very challenging, due to the complex and broad-spectrum actions of this cytokine in cancer progression and microenvironment architecture.

Furthermore, adverse side effects can be expected from systemic administration and/or broad-spectrum action of candidate agents.

The day's testimony left Mrs. Herrera's relatives calling for a broad investigation into the actions of officers involved in the arrest.

This specific compartmentalization of Fyn to the NMDAR complex via RACK1 has broad implications for the actions of alcohol on the channel.