We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders.
Their model provides a very simple mechanism for bringing together genes with a common transcriptional polarity.
However, even small viruses of eukaryotes carry signs of recombination bringing together genes from different sources, including hallmark genes that are not found next to each other in prokaryotic viruses.
The non-equilibrium type of hyperstructure is exemplified by the nucleolus in eukaryotic cells and, by "nucleolus-like" microcompartments in prokaryotic cells where rRNA genes are transcribed and where ribosomal proteins assemble onto the nascent rRNA, so bringing together genes encoding rRNA and rproteins, nascent RNA, as well as nascent ribosomal proteins and their genes [ 119].
When these chromosomes break, and their parts then join to form a 9-22 hybrid chromosome, they bring together two genes, called BCR and ABL.
That these pairs show coexpression very similar to ancestrally linked pairs (fig. 1) seems only compatible with the hypothesis that natural selection promotes chromosomal rearrangements that bring together coexpressed genes.
In addition, chromosomal rearrangements can juxtapose portions of coding sequence from two genes in the same orientation, leading to oncogenic fusion genes, or bring together an intact gene with the regulatory machinery of another gene, causing dysregulated gene expression.
One of the major goals is to bring together experts for each gene family to allow them to perform their annotation through the ORCAE annotation website, which in due time will synchronized with major public databases such as NCBI or Uniprot.
Two-way hierarchical clustering was used to bring together sets of samples and genes with similar expression pattern.
If we can begin to bring together many large datasets of gene expression data free from dataset-specific bias the opportunity exists to create a highly valuable resource.
