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Considering that the pioneering work of Dodge and Romig (DR) (1929) in acceptance sampling, which has survived decades of academic debate and practice, arrived before the formalization of hypothesis testing by NP, the question is why bring hypothesis testing into the discussion at all.
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Traditional theory misses the fact that that "bringing hypotheses to bear on facts is an activity that goes on, ultimately, not in the savant's head but in industry" (p. 196).
However, the lack of efficacy of anti-inflammatory/immunosuppressive therapy in concert with experimental evidence suggesting that inflammation is not necessary for the progression to fibrosis has brought this hypothesis into question.
This might bring us to hypothesis that volume of oral fluids taken is more important than the energy that they posses based on carbohydrate concentration.
In the present review, we bring forward the hypothesis that plants could maximize ant-derived rewards (i.e. defence) through secondary metabolite-mediated ant manipulation (see Fig. 4).
Our results bring new functional hypothesis that could be tested experimentally and enrich our knowledge on this poorly understood secretion system.
We discuss our findings in the context of functional specialization and bring many testable hypotheses to light.
These hypotheses bring us closer to a mechanistic model of how variants affect gene expression in specific cells and conditions, which can then be validated using modern perturbation tools such as CRISPR-mediated mutagenesis.
We believe that the integration of networks and heterogeneous data sources will help us bring about new hypotheses to infer the drug-disease associations and even speed up drug development processes.
Nevertheless, this hypothesis does not fully answer the question of whether plants can actively assess ants' identity and activity, and further investigations are required to bring forward alternative hypotheses regarding specific mechanisms (e.g. chemical, mechanical or electrical cues) by which this could be achieved.
Starting from recent advances in the field, we bring forward several hypotheses on the putative role of secondary metabolites in EFNs in plant ant relationships and identify key outstanding issues that need to be addressed to fully understand these fascinating associations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com