Sentence examples for bring about repression from inspiring English sources

The activator is the primary regulator necessary to increase expression from the promoter; the repressor in this case is the secondary regulator that "antagonizes" the activity of the activator to bring about repression of an otherwise activated promoter.

Multitude of chromatin (histone) modifying enzymes, including deacetylases, methyltranferases and demethylases, are proposed to be among the many transcriptional regulators that interact non-covalently with SUMO to bring about repression (Yang et al., 2003; Rosendorff et al., 2006).

We suggest that PRH octamers wrap DNA in order to bring about transcriptional repression.

In 1986, President Ronald Reagan charged Mandela and the ANC engaged in "calculated terror... the mining of roads, the bombings of public places, designed to bring about further repression" and in 1988 the State Department listed the ANC among "organizations that engage in terrorism" because civilians had "been victims of incidents claimed by or attributed to the ANC".

This observation led us to conclude that both these pathways are contributing equally to bring about gastrin repression (Fig. 4D).

Under hypoxic conditions, E2F1 and E2F4 simultaneously bind the Brca1 promoter at two adjacent E2F sites to bring about transcriptional repression of BRCA1 gene expression [30], [31].

To investigate transcription factors that can bring about transcription repression of DNA repair genes upon HDAC inhibition, we focused our attention on the E2F transcription factors.

MBD1 associates with the H3K9 methyl transferase SUV39H1-HP1 complex to bring about transcriptional repression [ 40].

PRH binds directly to sites located in the promoter or intron regions of several genes to bring about transcriptional repression (Table 1).

One model for Cyc8 Tup1 activity purports that it recruits HDACs to target promoters which deacetylate adjacent histones to bring about gene repression [29,63].

PRH interacts with members of the Groucho/TLE co-repressor protein family and may recruit TLE proteins to a subset of target promoters to bring about transcriptional repression [ 18].