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The induction of a protracted response to a brief stimulus is a form of cellular memory.
Understanding these nonlinearities in the BOLD response is important for design and the analysis of rapid event-related fMRI experiments with brief stimulus presentations.
In neurons with voltage-gated channels, we reproduced the observations where a brief stimulus to the proximal ascending dendritic branch of a pyramidal cell triggers a local action potential but a long stimulus triggers a somal action potential.
I show that chronic neuromuscular stimulation accelerates synapse elimination but that this acceleration is dependent on the temporal pattern in which the stimuli are presented: brief stimulus trains containing 100 Hz bursts of stimuli produce this acceleration whereas the same number of stimuli presented continuously at 1 Hz do not.
(I'm assuming that you are using a brief stimulus current, so the effect on the shape of the cell's spike isn't just caused by temporal overlap of the stimulus current and the spike waveform) Did you get that understanding from a book, or from your own experience, either with "real" experiments on living cells or "computational" experiments on models?
When organized percepts are easy to come by, gradations in intelligence do not seem to matter; when some barrier to organization is imposed (as by brief stimulus exposure), however, then the effect on perception of such differences among individuals may show up.
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depolarizations in response to two brief stimuli.
Simulation shows prolonged depolarizations in response to two brief stimuli.
The analysis of these signals currently relies on models of impulse hemodynamic responses to brief stimuli.
The occurrence of brief stimuli (events) can be parameterized by a minimal stimulus-onset asynchrony and a stimulus transition table.
Following brief stimuli, cholinergic modulation reveals a latent afterdepolarization response in mossy cells that can extend the duration of stimulus-evoked depolarization by >100 msec.
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