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An oblique bridging channel forms between the left and right anterior cardinal veins, which shifts systemic venous return to the right SVC and into the right atrium.
Enlarge inset depicts proliferating and non-proliferating double stained CD8+ T cells in the bridging channel.
MZ bridging channel positioning facilitates DC capture of blood-borne particulate antigen and rapid movement to T zone.
Following particulate antigen exposure, DCs migrate in a CCR7-dependent manner from the bridging channel in to the T zone where they present antigen to helper T cells.
Immunofluorescence showing localization of double stained CD8α+ T cells that are proliferating (EdU+, yellow arrows) or non-proliferating (Edu−, blue arrows) within the bridging channel and MZ.
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Marginal zone bridging channels and their possible role in cell traffic.
After immunization of plt mice, T cells and dendritic cells colocalize in the superficial cortex of lymph nodes and in splenic bridging channels, but not in T cell zones.
Immunofluorescent microscopy of frozen splenic sections also revealed HEL-positive cells within the marginal zone, red-pulp, bridging channels, and T cell zone of NZB, but not B6 dTg mice.
10.7554/eLife.00757.006 Figure 3. EBis is required for DC positioning in MZ bridging channels and LN interfollicular regions.
Under homeostatic conditions, EBI2 has a dominant influence and promotes positioning in MZ bridging channels.
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CEO of Professional Science Editing for Scientists @ prosciediting.com