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In control cells, persisting chromosome bridges were resolved in 680 min, whereas in ULK3-depleted cells, this resolution time was dramatically reduced to 300 min. Thus, our experiments demonstrate that ULK3 plays an essential role in supporting the Aurora B-dependent abscission checkpoint in response to either defective nuclear pore assembly or lagging chromosomes.
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It is unclear how these bridges are resolved, but they appear to induce the formation of nuclear buds and micronuclei containing fragmented DNA in the daughter cells (Pampalona et al., 2010).
Disagreements were resolved in consensus.
All were resolved in short order.
Discrepancies were resolved in consensus.
Discordances were resolved in consensus.
Aurora B is the key regulator of abscission timing, which responds to chromosome bridge formation by delaying abscission to stabilize the intercellular canal until the chromosome bridge is resolved.
But little was resolved in Oslo.
"They will be resolved in the next week".
It was resolved in Voyager 2 images.
"This issue was resolved in 2008.
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