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Experiments using different lots of HU show variability in the severity of the HU-induced chromatin bridge defect in the smc-5 (ok2421 ) mutant, ranging from 60 to >90% frequency for this defect.
Both the HU-enhanced chromatin bridge defect and a reduction in mitotic germ cells in the smc-5 (ok2421 ) mutant backgrounds are suppressed by the brc-1 (tm1145 ) mutation.
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Healing may be achieved by immobilization with or without internal fixation and by transplantation of bone to bridge the defect.
The original cortical scaffold was used to bridge the defect, filled with an autogenous particulate bone graft in 14 goats, whereas platelet-rich-plasma (PRP) was added in another 14 goats.
A three-month investigation by the L.I.R.R. concluded that at 1 32 p.m. on Jan . 24 as a double-decker train moved eastbound at 42 miles per hour just west of the Stony Hollow Road bridge, the defect contributed to conditions that caused a wheel to slip off a curved section of track.
The use of an external fixator for bone transport to bridge a defect is an alternative to the shortening and staged reconstruction.
The bone regenerated to bridge the defect and formed new cortex in the region with the 3 mm passage as shown in Figure 2 e) but not in those without a passage as shown in Figure 2(f).
Nerve guidance conduits fabricated from natural polymers such as collagen are a common alternative to bridge nerve defects.
In this chapter we discuss the future perspective of nerve reconstruction with focus on signal transduction mechanisms and new avenues to bridge nerve defects using nanomodified graft surfaces.
The use of genetically modified, reconstituted PN grafts to bridge tissue defects may provide new therapeutic strategies for the treatment of both CNS and PNS injuries.
Consistent with our in vitro observations, Epo-releasing scaffolds were found to be more potent in bridging the defect than BMP-2 loaded scaffolds, as determined by computed tomography (CT) scanning, fluorescent imaging and histological analyses.
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