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If Turkey were admitted to the European Union, it would be a bridge binding these two worlds.
At the promoter site, Ski and SnoN recruit the HDAC repressor complex to Smads, acting as a bridge binding N-CoR through the DH domain [7].
The EtpA glycoprotein appears to act as a molecular bridge, binding the exposed regions of FliC at the flagellar tip and host surface structures [ 24, 25].
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The literature is inconsistent regarding the location of the cyanide binding site on the C-cluster of CODH, with some spectroscopic studies suggesting cyanide binds to iron and others suggesting multiple, perhaps bridging, binding sites (22, 23, 40, 41, 45− 45−.
Furthermore, cTnI(1 167) slowed MgADP release rate and enhanced cross-bridge binding.
Three different rates of Tn exchange were observed that were dependent on calcium concentration and strong cross-bridge binding that strongly support the three-state model.
Significantly, we can now fit into the reconstruction an atomic model of the thin filament independent of any cross-bridge binding.
This would increase the probability of cross-bridge binding to actin, resulting in a greater number of cross-bridges exerting force during the twitch contraction.
This phase indicates that cross-bridge binding can activate the thin filament beyond the level of activation induced by Ca2+ alone.
Even minimal decrease in muscle pH interferes with cross-bridge binding and ATPase activity due to competitive binding and reduced enzyme function.
However, it remained unclear whether the slow phase is a consequence of cross-bridge binding or represents an intrinsic part of thin filament activation that rate-limits the force increase.
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