Sentence examples for bridge adaptor from inspiring English sources

In addition the MyD88-independent signaling pathway activates a TIR domain-containing adaptor (TRIF), which needs another bridge adaptor, the TRIF-related adaptor molecule (TRAM), and this leads to activation of TRAF3 that contributes to the activation of interferon regulatory factor (IRF) 3 [11], [11] and the late phase activation of NF-κB and MAP kinases [12].

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TRAM/TICAM-2 is used by Toll-like receptor 4 (TLR4) as a bridging adaptor during the mammalian innate immune response.

TIRAP/Mal acts as a bridging adaptor recruiting MyD88 to TLR2 or TLR4 [ 10].

miR-145 was shown to target the bridging adaptor MAL [ 63]. miR-21 inhibits the expression of proinflammatory regulator PDCD4 after TLR4 engagement [ 64].

In another study, miR-145 was found to target MAL, which is the bridging adaptor between TLR2- and TLR4-mediated MyD88-dependent signaling [ 58].

In addition, TIRAP (also known as MAL), another MyD88 adaptor-like protein that acts as a bridging adaptor for TLR2- and TLR4-mediated MyD88-dependent signalling pathways, has been identified as a target of miR-145 in hematopoietic stem/progenitor cells [ 31].

Shc proteins can serve as additional bridging adaptors between Grb2 and the tyrosine-phosphorylated receptors.

Zhao, T. et al. The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways.

The pseudoatomic structure derived from the cryo-EM reconstruction clearly demonstrates a model only compatible with the adaptor bridging mechanism, wherein the funnel-like AcrA hexamer forms an intermeshing cogwheel-like interaction with the α-barrel tip region of TolC.

In this report, we provide evidence showing that Tom1L1 is a regulated adaptor bridging activated EGFR with the endocytic machinery for internalization of activated EGFR.