Insulin growth factor binding protein-1 levels and its IGF-1 binding capacity are tightly regulated by insulin, with IGFBP-1, as a result, acting as a bridging molecule between the insulin and IGF systems (Sakai et al, 2001; Borai et al, 2007).
Being a multi-domain adaptor protein, FE65 has been reported to serve as a bridging molecule between the cytosolic tails of APP and a number of apolipoprotein E (ApoE) receptors including low-density lipoprotein receptor-related protein (LRP1), ApoER2 and very low-density lipoprotein receptor (VLDLR).
This is in concordance with the suggested function of lactadherin, i.e. the glycoprotein operates as a bridging molecule between PS-exposing apoptotic/necrotic cells and integrin receptors on macrophages [16, 29].
Metalloporphyrins M-OEP (M = Co II), Cu II), Zn II), Ru II), Fe III) and Ni II), OEP = 2,3,7,8,12,13,17,18-Octaethyl-21H,23H-porphine) were deposited on glassy carbon electrodes that had been previously modified by using NaOH and 4-aminopyridine, which served as a bridging molecule between the metalloporphyrins and the electrode surface.
Bacterial uptake is promoted by fibronectin which acts as a bridging molecule between integrin α5β1 on the cell surface and the S. aureus fibronectin-binding proteins [16], [19], [22], [23].
In this model, C1q acts as a bridging molecule between circulating ICs containing HCV-Cp and the vascular endothelium [ 18].
Here, again, seems that MFG-E8 works as a bridging molecule between apoptotic cells/neurons and microglia [ 19].
First, the soluble form of fibrinogen could serve as a bridging molecule between tumour cells and the surrounding microenvironment.
MFG-E8 promotes the phagocytosis of apoptotic cells by serving as a bridging molecule between apoptotic cells and phagocytes.
Members of this family may function as a bridging molecule between the nutritional signaling pathway and the hormone biosynthesis pathway in Arabidopsis [ 68].
