Exact(2)
The strong differentiation of the Corsican sheep breed suggests a similar history.
The large number of monomorphic SNPs and rare alleles detected for this breed suggests that a strong drift effect has taken place.
Similar(58)
We uncovered a set of hemangiosarcoma-associated genes peculiar to a single dog breed suggesting these are modulated by (or with) heritable traits that may influence risk for this cancer.
The high Fst values within each breed suggested that the level of genetic differentiation was high among herds and motivated further investigation.
The cumulative exclusion probability (PE) was 0.999 in each breed, suggesting that the loci would be suitable for donkey parentage testing.
In five out of 54 cases, the reverse was observed with the favourable allele originating from the Merino breed, suggesting the presence of cryptic QTL.
On the other hand, the individual contribution of the remaining five breeds to this group ranged from 63% in the case of the Murrah breed to 90% in the Toda breed, suggesting a decline in the D-loop haplotype complexity in these five breeds as one moved away from the sampling sites of the Mehsana/Surati/Pandharpuri animals.
The familial and molecular basis of the defect in both species is poorly understood although a previous description of the pattern of inheritance in a canine model in the Newfoundland dog breed suggested either an autosomal dominant with incomplete penetrance or a polygenic mode of inheritance (Pyle and Patterson 1976).
How the presumed defective allele was introduced into the Brown Swiss cattle population in Switzerland via dam J or her ancestors remains unclear; however, during our study nasolacrimal duct fistula was incidentally identified in two non-related cows of the same breed, suggesting that this trait is not limited to the family of dam J.
The interaction in gene × tissue for differentially expressed genes between breeds suggests that animal breeding has targeted differentially each tissue's transcriptome.
The increased risk in specific breeds suggests a significant genetic component, influencing the power of mapping the genetic risk factors underlying SLO.
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